Diverse evolutionary patterns of pneumococcal antigens identified by pangenome-wide immunological screening

Characterizing the immune response to pneumococcal proteins is critical in understanding this bacterium’s epidemiology and vaccinology. Probing a custom-designed proteome microarray with sera from 35 healthy US adults revealed a continuous distribution of IgG affinities for 2,190 potential antigens...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Croucher, Nicholas J., Campo, Joseph J., Le, Timothy Q., Liang, Xiaowu, Bentley, Stephen D., Hanage, William P., Lipsitch, Marc
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5255586/
https://ncbi.nlm.nih.gov/pubmed/28053228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1613937114
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