Pharmacodynamics of Pulse Dosing versus Standard Dosing: In Vitro Metronidazole Activity against Bacteroides fragilis and Bacteroides thetaiotaomicron

Pulse dosing is a novel approach to dosing that produces escalating antibiotic levels early in the dosing interval followed by a prolonged dose-free period. Antibiotic is frontloaded by means of four sequential bolus injections, after which antibiotic levels are allowed to diminish until the next do...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Ibrahim, Khalid H., Gunderson, Brent W., Hermsen, Elizabeth D., Hovde, Laurie B., Rotschafer, John C.
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2004
Témata:	Pharmacology
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC525458/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15504841/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.48.11.4195-4199.2004
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