Pharmacodynamics of Pulse Dosing versus Standard Dosing: In Vitro Metronidazole Activity against Bacteroides fragilis and Bacteroides thetaiotaomicron

Pulse dosing is a novel approach to dosing that produces escalating antibiotic levels early in the dosing interval followed by a prolonged dose-free period. Antibiotic is frontloaded by means of four sequential bolus injections, after which antibiotic levels are allowed to diminish until the next do...

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Detalhes bibliográficos
Main Authors: Ibrahim, Khalid H., Gunderson, Brent W., Hermsen, Elizabeth D., Hovde, Laurie B., Rotschafer, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC525458/
https://ncbi.nlm.nih.gov/pubmed/15504841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.11.4195-4199.2004
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