Decreased Bioavailability of Rifampin and Other Antituberculosis Drugs in Patients with Advanced Human Immunodeficiency Virus Disease

We evaluated the effects of human immunodeficiency virus (HIV) disease on pharmacokinetics of antituberculosis medications by measuring concentrations of isoniazid and rifampin in blood and of pyrazinamide and ethambutol in urine. Peak concentration and exposure were reduced for rifampin, and rapid...

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Main Authors: Gurumurthy, Prema, Ramachandran, Geetha, Hemanth Kumar, A. K., Rajasekaran, S., Padmapriyadarsini, C., Swaminathan, Soumya, Bhagavathy, S., Venkatesan, P., Sekar, L., Mahilmaran, A., Ravichandran, N., Paramesh, P.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2004
Teme:
Pharmacology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC525439/
https://ncbi.nlm.nih.gov/pubmed/15504887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.11.4473-4475.2004
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