Hormetic effect of panaxatriol saponins confers neuroprotection in PC12 cells and zebrafish through PI3K/AKT/mTOR and AMPK/SIRT1/FOXO3 pathways

Hormesis is an adaptive response of living organisms to a moderate stress. However, its biomedical implication and molecular mechanisms remain to be intensively investigated. Panaxatriol saponins (PTS) is the major bioactive components extracted from Panax notoginseng, a widely used herbal medicine...

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Pubblicato in:Sci Rep
Autori principali: Zhang, Chao, Li, Chuwen, Chen, Shenghui, Li, Zhiping, Ma, Lijuan, Jia, Xuejing, Wang, Kai, Bao, Jiaolin, Liang, Yeer, Chen, Meiwan, Li, Peng, Su, Huanxing, Lee, Simon Ming Yuen, Liu, Kechun, Wan, Jian-Bo, He, Chengwei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253660/
https://ncbi.nlm.nih.gov/pubmed/28112228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41082
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