Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways

Berberine (BBR) is a renowned natural compound that exhibits potent neuroprotective activities. However, the cellular and molecular mechanisms are still unclear. Hormesis is an adaptive mechanism generally activated by mild oxidative stress to protect the cells from further damage. Many phytochemica...

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Udgivet i:Redox Biol
Main Authors: Zhang, Chao, Li, Chuwen, Chen, Shenghui, Li, Zhiping, Jia, Xuejing, Wang, Kai, Bao, Jiaolin, Liang, Yeer, Wang, Xiaotong, Chen, Meiwan, Li, Peng, Su, Huanxing, Wan, Jian-Bo, Lee, Simon Ming Yuen, Liu, Kechun, He, Chengwei
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107737/
https://ncbi.nlm.nih.gov/pubmed/27835779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.10.019
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