Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways

Berberine (BBR) is a renowned natural compound that exhibits potent neuroprotective activities. However, the cellular and molecular mechanisms are still unclear. Hormesis is an adaptive mechanism generally activated by mild oxidative stress to protect the cells from further damage. Many phytochemica...

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Publicat a:Redox Biol
Autors principals: Zhang, Chao, Li, Chuwen, Chen, Shenghui, Li, Zhiping, Jia, Xuejing, Wang, Kai, Bao, Jiaolin, Liang, Yeer, Wang, Xiaotong, Chen, Meiwan, Li, Peng, Su, Huanxing, Wan, Jian-Bo, Lee, Simon Ming Yuen, Liu, Kechun, He, Chengwei
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2016
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107737/
https://ncbi.nlm.nih.gov/pubmed/27835779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.10.019
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