Berberine protects against 6-OHDA-induced neurotoxicity in PC12 cells and zebrafish through hormetic mechanisms involving PI3K/AKT/Bcl-2 and Nrf2/HO-1 pathways

Berberine (BBR) is a renowned natural compound that exhibits potent neuroprotective activities. However, the cellular and molecular mechanisms are still unclear. Hormesis is an adaptive mechanism generally activated by mild oxidative stress to protect the cells from further damage. Many phytochemica...

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Dettagli Bibliografici
Pubblicato in:Redox Biol
Autori principali: Zhang, Chao, Li, Chuwen, Chen, Shenghui, Li, Zhiping, Jia, Xuejing, Wang, Kai, Bao, Jiaolin, Liang, Yeer, Wang, Xiaotong, Chen, Meiwan, Li, Peng, Su, Huanxing, Wan, Jian-Bo, Lee, Simon Ming Yuen, Liu, Kechun, He, Chengwei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2016
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5107737/
https://ncbi.nlm.nih.gov/pubmed/27835779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.10.019
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