Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations

Nasopharyngeal carcinoma (NPC) is an aggressive head and neck cancer characterized by Epstein-Barr virus (EBV) infection and dense lymphocyte infiltration. The scarcity of NPC genomic data hinders the understanding of NPC biology, disease progression and rational therapy design. Here we performed wh...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Li, Yvonne Y, Chung, Grace T. Y., Lui, Vivian W. Y., To, Ka-Fai, Ma, Brigette B. Y., Chow, Chit, Woo, John K, S., Yip, Kevin Y., Seo, Jeongsun, Hui, Edwin P., Mak, Michael K. F., Rusan, Maria, Chau, Nicole G., Or, Yvonne Y. Y., Law, Marcus H. N., Law, Peggy P. Y., Liu, Zoey W. Y., Ngan, Hoi-Lam, Hau, Pok-Man, Verhoeft, Krista R., Poon, Peony H. Y., Yoo, Seong-Keun, Shin, Jong-Yeon, Lee, Sau-Dan, Lun, Samantha W. M., Jia, Lin, Chan, Anthony W. H., Chan, Jason Y. K., Lai, Paul B. S., Fung, Choi-Yi, Hung, Suet-Ting, Wang, Lin, Chang, Ann Margaret V., Chiosea, Simion I., Hedberg, Matthew L., Tsao, Sai-Wah, van Hasselt, Andrew C., Chan, Anthony T. C., Grandis, Jennifer R., Hammerman, Peter S., Lo, Kwok-Wai
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5253631/
https://ncbi.nlm.nih.gov/pubmed/28098136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms14121
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