Inhibition of the replication of hepatitis B virus in vitro by 2',3'-dideoxy-3'-thiacytidine and related analogues.

Several 2',3'-dideoxy-3'-thiapyrimidine nucleosides were studied for their ability to inhibit hepatitis B virus (HBV) DNA replication in a HBV-transfected cell line (2.2.15). 2',3'-Dideoxy-3'-thiacytidine (SddC) and 5-fluoro-2',3'-dideoxy-3'-thiacytidine(5-FSddC) were found to be the most potent ant...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Doong, S L, Tsai, C H, Schinazi, R F, Liotta, D C, Cheng, Y C
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1991
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52535/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1656445/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.19.8495
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