Two sites in the tissue factor extracellular domain mediate the recognition of the ligand factor VIIa.
Tissue factor (TF) binds the serine protease coagulation factor VIIa and initiates the coagulation protease cascade by forming a catalytic cofactor-enzyme complex. Using a photoactivatable crosslinking reagent coupled to factor VIIa, we have identified interactive sites in the amino-terminal (residu...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1991
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52522/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1924302/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.19.8430 |
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