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In Vitro Models Reveal Differences in the Developmental Neurotoxicity of an Environmental Polycylic Aromatic Hydrocarbon Mixture Compared to Benzo[a]pyrene: Neuronotypic PC12 Cells and Embryonic Neural Stem Cells

In addition to their carcinogenic activity, polycyclic aromatic hydrocarbons (PAHs) are suspected to be developmental neurotoxicants. We evaluated the effects of PAHs with two in vitro models that assess distinct “decision nodes” in neurodifferentiation: neuronotypic PC12 cells, which characterize t...

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Bibliografiske detaljer
Udgivet i:Toxicology
Main Authors: Slotkin, Theodore A., Skavicus, Samantha, Card, Jennifer, Di Giulio, Richard T., Seidler, Frederic J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5250555/
https://ncbi.nlm.nih.gov/pubmed/28049045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2016.12.008
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