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In Vitro Models Reveal Differences in the Developmental Neurotoxicity of an Environmental Polycylic Aromatic Hydrocarbon Mixture Compared to Benzo[a]pyrene: Neuronotypic PC12 Cells and Embryonic Neural Stem Cells

In addition to their carcinogenic activity, polycyclic aromatic hydrocarbons (PAHs) are suspected to be developmental neurotoxicants. We evaluated the effects of PAHs with two in vitro models that assess distinct “decision nodes” in neurodifferentiation: neuronotypic PC12 cells, which characterize t...

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Publicat a:Toxicology
Autors principals: Slotkin, Theodore A., Skavicus, Samantha, Card, Jennifer, Di Giulio, Richard T., Seidler, Frederic J.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5250555/
https://ncbi.nlm.nih.gov/pubmed/28049045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tox.2016.12.008
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