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Altered Mineralization of Human Osteoarthritic Osteoblasts Is Attributable to Abnormal Type I Collagen Production

OBJECTIVE: Bone tissue in osteoarthritis (OA) is composed of abundant undermineralized osteoid matrix. The aim of this study was to investigate the mechanisms responsible for this abnormal matrix, using in vitro OA subchondral osteoblasts. METHODS: Primary normal and OA osteoblasts were prepared fro...

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Bibliografiske detaljer
Udgivet i:Arthritis Rheum
Main Authors: Couchourel, Denis, Aubry, Isabelle, Delalandre, Aline, Lavigne, Martin, Martel-Pelletier, Johanne, Pelletier, Jean-Pierre, Lajeunesse, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5250342/
https://ncbi.nlm.nih.gov/pubmed/19404930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24489
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