Altered Mineralization of Human Osteoarthritic Osteoblasts Is Attributable to Abnormal Type I Collagen Production

OBJECTIVE: Bone tissue in osteoarthritis (OA) is composed of abundant undermineralized osteoid matrix. The aim of this study was to investigate the mechanisms responsible for this abnormal matrix, using in vitro OA subchondral osteoblasts. METHODS: Primary normal and OA osteoblasts were prepared fro...

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Detalhes bibliográficos
Publicado no:Arthritis Rheum
Main Authors: Couchourel, Denis, Aubry, Isabelle, Delalandre, Aline, Lavigne, Martin, Martel-Pelletier, Johanne, Pelletier, Jean-Pierre, Lajeunesse, Daniel
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5250342/
https://ncbi.nlm.nih.gov/pubmed/19404930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24489
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