Altered Mineralization of Human Osteoarthritic Osteoblasts Is Attributable to Abnormal Type I Collagen Production

OBJECTIVE: Bone tissue in osteoarthritis (OA) is composed of abundant undermineralized osteoid matrix. The aim of this study was to investigate the mechanisms responsible for this abnormal matrix, using in vitro OA subchondral osteoblasts. METHODS: Primary normal and OA osteoblasts were prepared fro...

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Vydáno v:Arthritis Rheum
Hlavní autoři: Couchourel, Denis, Aubry, Isabelle, Delalandre, Aline, Lavigne, Martin, Martel-Pelletier, Johanne, Pelletier, Jean-Pierre, Lajeunesse, Daniel
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5250342/
https://ncbi.nlm.nih.gov/pubmed/19404930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24489
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