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Class II Integrase Mutants with Changes in Putative Nuclear Localization Signals Are Primarily Blocked at a Postnuclear Entry Step of Human Immunodeficiency Virus Type 1 Replication

Integrase has been implicated in human immunodeficiency virus type 1 (HIV-1) nuclear import. Integrase analyses, however, can be complicated by the pleiotropic nature of mutations: whereas class I mutants are integration defective, class II mutants display additional assembly and/or reverse transcri...

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Udgivet i:J Virol
Principais autores: Lu, Richard, Limón, Ana, Devroe, Eric, Silver, Pamela A., Cherepanov, Peter, Engelman, Alan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
Fag:
Replication
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC525011/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15542626/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.23.12735-12746.2004
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