Transmission of Prions from Mule Deer and Elk with Chronic Wasting Disease to Transgenic Mice Expressing Cervid PrP

We generated mice expressing cervid prion protein to produce a transgenic system simulating chronic wasting disease (CWD) in deer and elk. While normal mice were resistant to CWD, these transgenic mice uniformly developed signs of neurological dysfunction ∼230 days following intracerebral inoculatio...

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Autors principals: Browning, Shawn R., Mason, Gary L., Seward, Tanya, Green, Mike, Eliason, Gwyneth A. J., Mathiason, Candace, Miller, Michael W., Williams, Elizabeth S., Hoover, Ed, Telling, Glenn C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC524991/
https://ncbi.nlm.nih.gov/pubmed/15542685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.23.13345-13350.2004
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