Mutation of All Runx (AML1/Core) Sites in the Enhancer of T-Lymphomagenic SL3-3 Murine Leukemia Virus Unmasks a Significant Potential for Myeloid Leukemia Induction and Favors Enhancer Evolution toward Induction of Other Disease Patterns

SL3-3 murine leukemia virus is a potent inducer of T-lymphomas in mice. Using inbred NMRI mice, it was previously reported that a mutant of SL3-3 with all enhancer Runx (AML1/core) sites disrupted by 3-bp mutations (SL3-3dm) induces predominantly non-T-cell tumors with severely extended latency (S....

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Detalles Bibliográficos
Main Authors: Sørensen, Karina Dalsgaard, Quintanilla-Martinez, Leticia, Kunder, Sandra, Schmidt, Jörg, Pedersen, Finn Skou
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC524987/
https://ncbi.nlm.nih.gov/pubmed/15542674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.23.13216-13231.2004
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