ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis

ASXL1 is frequently mutated in a spectrum of myeloid malignancies with poor prognosis. Loss of Asxl1 leads to myelodysplastic syndrome–like disease in mice; however, the underlying molecular mechanisms remain unclear. We report that ASXL1 interacts with the cohesin complex, which has been shown to g...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Adv
Auteurs principaux: Li, Zhaomin, Zhang, Peng, Yan, Aimin, Guo, Zhengyu, Ban, Yuguang, Li, Jin, Chen, Shi, Yang, Hui, He, Yongzheng, Li, Jianping, Guo, Ying, Zhang, Wen, Hajiramezanali, Ehsan, An, Huangda, Fajardo, Darlene, Harbour, J. William, Ruan, Yijun, Nimer, Stephen D., Yu, Peng, Chen, Xi, Xu, Mingjiang, Yang, Feng-Chun
Format: Artigo
Langue:Inglês
Publié: American Association for the Advancement of Science 2017
Sujets:
Research Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5249256/
https://ncbi.nlm.nih.gov/pubmed/28116354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.1601602
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