Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon

Animal models are needed to better understand the pathogenic mechanisms of Zika virus (ZIKV) and to evaluate candidate medical countermeasures. Adult mice infected with ZIKV develop a transient viremia, but do not demonstrate signs of morbidity or mortality. Mice deficient in type I or a combination...

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Publicado en:PLoS Negl Trop Dis
Main Authors: Smith, Darci R., Hollidge, Bradley, Daye, Sharon, Zeng, Xiankun, Blancett, Candace, Kuszpit, Kyle, Bocan, Thomas, Koehler, Jeff W., Coyne, Susan, Minogue, Tim, Kenny, Tara, Chi, Xiaoli, Yim, Soojin, Miller, Lynn, Schmaljohn, Connie, Bavari, Sina, Golden, Joseph W.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5249252/
https://ncbi.nlm.nih.gov/pubmed/28068342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005296
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