Neuropathogenesis of Zika Virus in a Highly Susceptible Immunocompetent Mouse Model after Antibody Blockade of Type I Interferon

Animal models are needed to better understand the pathogenic mechanisms of Zika virus (ZIKV) and to evaluate candidate medical countermeasures. Adult mice infected with ZIKV develop a transient viremia, but do not demonstrate signs of morbidity or mortality. Mice deficient in type I or a combination...

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發表在:PLoS Negl Trop Dis
Main Authors: Smith, Darci R., Hollidge, Bradley, Daye, Sharon, Zeng, Xiankun, Blancett, Candace, Kuszpit, Kyle, Bocan, Thomas, Koehler, Jeff W., Coyne, Susan, Minogue, Tim, Kenny, Tara, Chi, Xiaoli, Yim, Soojin, Miller, Lynn, Schmaljohn, Connie, Bavari, Sina, Golden, Joseph W.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2017
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5249252/
https://ncbi.nlm.nih.gov/pubmed/28068342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0005296
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