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A physarum-inspired prize-collecting steiner tree approach to identify subnetworks for drug repositioning

BACKGROUND: Drug repositioning can reduce the time, costs and risks of drug development by identifying new therapeutic effects for known drugs. It is challenging to reposition drugs as pharmacological data is large and complex. Subnetwork identification has already been used to simplify the visualiz...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:BMC Syst Biol
Prif Awduron: Sun, Yahui, Hameed, Pathima Nusrath, Verspoor, Karin, Halgamuge, Saman
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BioMed Central 2016
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5249043/
https://ncbi.nlm.nih.gov/pubmed/28105946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12918-016-0371-3
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