Integrin-Linked Kinase Is Necessary for the Development of Diet-Induced Hepatic Insulin Resistance

The liver extracellular matrix (ECM) expands with high-fat (HF) feeding. This finding led us to address whether receptors for the ECM, integrins, are key to the development of diet-induced hepatic insulin resistance. Integrin-linked kinase (ILK) is a downstream integrin signaling molecule involved i...

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Veröffentlicht in:Diabetes
Hauptverfasser: Williams, Ashley S., Trefts, Elijah, Lantier, Louise, Grueter, Carrie A., Bracy, Deanna P., James, Freyja D., Pozzi, Ambra, Zent, Roy, Wasserman, David H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2017
Schlagworte:
Metabolism
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248997/
https://ncbi.nlm.nih.gov/pubmed/27899483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0484
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