Peroxisome Proliferator-Activated Receptor γ Regulates the V-Ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1/microRNA-27a Axis to Reduce Endothelin-1 and Endothelial Dysfunction in the Sickle Cell Mouse Lung

Pulmonary hypertension (PH), a serious complication of sickle cell disease (SCD), causes significant morbidity and mortality. Although a recent study determined that hemin release during hemolysis triggers endothelial dysfunction in SCD, the pathogenesis of SCD-PH remains incompletely defined. This...

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Veröffentlicht in:Am J Respir Cell Mol Biol
Hauptverfasser: Kang, Bum-Yong, Park, Kathy, Kleinhenz, Jennifer M., Murphy, Tamara C., Sutliff, Roy L., Archer, David, Hart, C. Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Thoracic Society 2017
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248964/
https://ncbi.nlm.nih.gov/pubmed/27612006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0166OC
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