Modified High-Molecular-Weight Hyaluronan Promotes Allergen-Specific Immune Tolerance

The extracellular matrix in asthmatic lungs contains abundant low-molecular-weight hyaluronan, and this is known to promote antigen presentation and allergic responses. Conversely, high-molecular-weight hyaluronan (HMW-HA), typical of uninflamed tissues, is known to suppress inflammation. We investi...

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Detalhes bibliográficos
Publicado no:Am J Respir Cell Mol Biol
Main Authors: Gebe, John A., Yadava, Koshika, Ruppert, Shannon M., Marshall, Payton, Hill, Paul, Falk, Ben A., Sweere, Johanna M., Han, Hongwei, Kaber, Gernot, Medina, Carlos, Mikecz, Katalin, Ziegler, Steven F., Balaji, Swathi, Keswani, Sundeep G., Perez, Vinicio A. de Jesus, Butte, Manish J., Nadeau, Kari, Altemeier, William A., Fanger, Neil, Bollyky, Paul L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2017
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248962/
https://ncbi.nlm.nih.gov/pubmed/27598620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2016-0111OC
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