Smooth Muscle Insulin-Like Growth Factor-1 Mediates Hypoxia-Induced Pulmonary Hypertension in Neonatal Mice

Insulin-like growth factor (IGF)-1 is a potent mitogen of vascular smooth muscle cells (SMCs), but its role in pulmonary vascular remodeling associated with pulmonary hypertension (PH) is not clear. In an earlier study, we implicated IGF-1 in the pathogenesis of hypoxia-induced PH in neonatal mice....

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Udgivet i:Am J Respir Cell Mol Biol
Main Authors: Sun, Miranda, Ramchandran, Ramaswamy, Chen, Jiwang, Yang, Qiwei, Raj, J. Usha
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248951/
https://ncbi.nlm.nih.gov/pubmed/27438786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1165/rcmb.2015-0388OC
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