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Pulmonary artery smooth muscle cell proliferation and migration in fetal lambs acclimatized to high-altitude long-term hypoxia: role of histone acetylation

High-altitude long-term hypoxia (LTH) is known to induce pulmonary arterial smooth muscle cell (PASMC) proliferation in the fetus, leading to pulmonary arterial remodeling and pulmonary hypertension of the newborn. The mechanisms underlying these conditions remain enigmatic however. We hypothesized...

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Autors principals: Yang, Qiwei, Lu, Ziyan, Ramchandran, Ramaswamy, Longo, Lawrence D., Raj, J. Usha
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532524/
https://ncbi.nlm.nih.gov/pubmed/23043075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00092.2012
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