Btk Inhibitor RN983 Delivered by Dry Powder Nose-only Aerosol Inhalation Inhibits Bronchoconstriction and Pulmonary Inflammation in the Ovalbumin Allergic Mouse Model of Asthma

Background: In allergen-induced asthma, activated mast cells start the lung inflammatory process with degranulation, cytokine synthesis, and mediator release. Bruton's tyrosine kinase (Btk) activity is required for the mast cell activation during IgE-mediated secretion. Methods: This study char...

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Pubblicato in:J Aerosol Med Pulm Drug Deliv
Autori principali: Phillips, Jonathan E., Renteria, Lorena, Burns, Lisa, Harris, Paul, Peng, Ruoqi, Bauer, Carla M.T., Laine, Dramane, Stevenson, Christopher S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2016
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248542/
https://ncbi.nlm.nih.gov/pubmed/27111445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jamp.2015.1210
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