Btk Inhibitor RN983 Delivered by Dry Powder Nose-only Aerosol Inhalation Inhibits Bronchoconstriction and Pulmonary Inflammation in the Ovalbumin Allergic Mouse Model of Asthma

Background: In allergen-induced asthma, activated mast cells start the lung inflammatory process with degranulation, cytokine synthesis, and mediator release. Bruton's tyrosine kinase (Btk) activity is required for the mast cell activation during IgE-mediated secretion. Methods: This study char...

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Bibliografiske detaljer
Udgivet i:J Aerosol Med Pulm Drug Deliv
Main Authors: Phillips, Jonathan E., Renteria, Lorena, Burns, Lisa, Harris, Paul, Peng, Ruoqi, Bauer, Carla M.T., Laine, Dramane, Stevenson, Christopher S.
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2016
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248542/
https://ncbi.nlm.nih.gov/pubmed/27111445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jamp.2015.1210
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