Btk Inhibitor RN983 Delivered by Dry Powder Nose-only Aerosol Inhalation Inhibits Bronchoconstriction and Pulmonary Inflammation in the Ovalbumin Allergic Mouse Model of Asthma

Background: In allergen-induced asthma, activated mast cells start the lung inflammatory process with degranulation, cytokine synthesis, and mediator release. Bruton's tyrosine kinase (Btk) activity is required for the mast cell activation during IgE-mediated secretion. Methods: This study char...

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Detaylı Bibliyografya
Yayımlandı:J Aerosol Med Pulm Drug Deliv
Asıl Yazarlar: Phillips, Jonathan E., Renteria, Lorena, Burns, Lisa, Harris, Paul, Peng, Ruoqi, Bauer, Carla M.T., Laine, Dramane, Stevenson, Christopher S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Mary Ann Liebert, Inc. 2016
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5248542/
https://ncbi.nlm.nih.gov/pubmed/27111445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/jamp.2015.1210
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