Improved Affinity of a Human Anti-Entamoeba histolytica Gal/GalNAc Lectin Fab Fragment by a Single Amino Acid Modification of the Light Chain

We previously produced, in Escherichia coli, a human monoclonal antibody Fab fragment, CP33, specific for the galactose- and N-acetyl-d-galactosamine-inhibitable lectin of Entamoeba histolytica. To prepare antibodies with a higher affinity to the lectin, recombination PCR was used to exchange Ser(91...

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Autors principals: Tachibana, Hiroshi, Matsumoto, Naohisa, Cheng, Xun-Jia, Tsukamoto, Hideo, Yoshihara, Eisaku
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Antibodies and Mediators of Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC524788/
https://ncbi.nlm.nih.gov/pubmed/15539510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CDLI.11.6.1085-1088.2004
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