Spontaneous Unfolding-Refolding of Fibronectin Type III Domains Assayed by Thiol Exchange: THERMODYNAMIC STABILITY CORRELATES WITH RATES OF UNFOLDING RATHER THAN FOLDING

Globular proteins are not permanently folded but spontaneously unfold and refold on time scales that can span orders of magnitude for different proteins. A longstanding debate in the protein-folding field is whether unfolding rates or folding rates correlate to the stability of a protein. In the pre...

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Udgivet i:J Biol Chem
Main Authors: Shah, Riddhi, Ohashi, Tomoo, Erickson, Harold P., Oas, Terrence G.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Protein Structure and Folding
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247667/
https://ncbi.nlm.nih.gov/pubmed/27909052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.760371
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