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Probing the Folded State of Fibronectin Type III Domains in Stretched Fibrils by Measuring Buried Cysteine Accessibility

Fibronectin (FN) is an extracellular matrix protein that is assembled into fibrils by cells during tissue morphogenesis and wound healing. FN matrix fibrils are highly elastic, but the mechanism of elasticity has been debated: it may be achieved by mechanical unfolding of FN-III domains or by a conf...

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Détails bibliographiques
Auteurs principaux: Lemmon, Christopher A., Ohashi, Tomoo, Erickson, Harold P.
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3143600/
https://ncbi.nlm.nih.gov/pubmed/21652701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.240028
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