The Production and Utilization of GDP-glucose in the Biosynthesis of Trehalose 6-Phosphate by Streptomyces venezuelae

Trehalose-6-phosphate synthase OtsA from streptomycetes is unusual in that it uses GDP-glucose as the donor substrate rather than the more commonly used UDP-glucose. We now confirm that OtsA from Streptomyces venezuelae has such a preference for GDP-glucose and can utilize ADP-glucose to some extent...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Asención Diez, Matías D., Miah, Farzana, Stevenson, Clare E. M., Lawson, David M., Iglesias, Alberto A., Bornemann, Stephen
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247666/
https://ncbi.nlm.nih.gov/pubmed/27903647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.758664
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