Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP)

LDL receptor-related protein 1 (LRP1) is a highly modular protein and the largest known mammalian endocytic receptor. LRP1 binds and internalizes many plasma components, playing multiple crucial roles as a scavenger and signaling molecule. One major challenge to studying LRP1 has been that it is dif...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: De Nardis, Camilla, Lössl, Philip, van den Biggelaar, Maartje, Madoori, Pramod K., Leloup, Nadia, Mertens, Koen, Heck, Albert J. R., Gros, Piet
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247663/
https://ncbi.nlm.nih.gov/pubmed/27956551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.758862
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