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Distinct Roles for the Hsp40 and Hsp90 Molecular Chaperones during Cystic Fibrosis Transmembrane Conductance Regulator Degradation in Yeast

Aberrant secreted proteins can be destroyed by ER-associated protein degradation (ERAD), and a prominent, medically relevant ERAD substrate is the cystic fibrosis transmembrane conductance regulator (CFTR). To better define the chaperone requirements during CFTR maturation, the protein was expressed...

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Bibliographische Detailangaben
Hauptverfasser: Youker, Robert T., Walsh, Peter, Beilharz, Traude, Lithgow, Trevor, Brodsky, Jeffrey L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Cell Biology 2004
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC524727/
https://ncbi.nlm.nih.gov/pubmed/15342786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E04-07-0584
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