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Computational modeling reveals how interplay between components of a GTPase-cycle module regulates signal transduction

Heterotrimeric G protein signaling is regulated by signaling modules composed of heterotrimeric G proteins, active G protein-coupled receptors (Rs), which activate G proteins, and GTPase-activating proteins (GAPs), which deactivate G proteins. We term these modules GTPase-cycle modules. The local co...

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Hlavní autoři: Bornheimer, Scott J., Maurya, Mano R., Farquhar, Marilyn Gist, Subramaniam, Shankar
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2004
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC524695/
https://ncbi.nlm.nih.gov/pubmed/15520372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407009101
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