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Computational modeling reveals how interplay between components of a GTPase-cycle module regulates signal transduction

Heterotrimeric G protein signaling is regulated by signaling modules composed of heterotrimeric G proteins, active G protein-coupled receptors (Rs), which activate G proteins, and GTPase-activating proteins (GAPs), which deactivate G proteins. We term these modules GTPase-cycle modules. The local co...

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Библиографические подробности
Главные авторы: Bornheimer, Scott J., Maurya, Mano R., Farquhar, Marilyn Gist, Subramaniam, Shankar
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2004
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC524695/
https://ncbi.nlm.nih.gov/pubmed/15520372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407009101
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