Survival factor-induced extracellular signal-regulated kinase phosphorylates BIM, inhibiting its association with BAX and proapoptotic activity

The “BH3-only” proapoptotic BCL-2 family members initiate the intrinsic apoptotic pathway. A small interfering RNA knockdown of BIM confirms this BH3-only member is important for the cytokine-mediated homeostasis of hematopoietic cells. We show here that the phosphorylation status of BIM controls it...

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Detaylı Bibliyografya
Asıl Yazarlar: Harada, Hisashi, Quearry, Bonnie, Ruiz-Vela, Antonio, Korsmeyer, Stanley J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2004
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC524459/
https://ncbi.nlm.nih.gov/pubmed/15486085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406837101
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