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Myelin proteolipid protein-specific CD4(+)CD25(+) regulatory cells mediate genetic resistance to experimental autoimmune encephalomyelitis

SJL mice are highly susceptible to experimental autoimmune encephalomyelitis (EAE) induced with myelin proteolipid protein (PLP) peptide 139-151, whereas H-2 congenic B10.S mice are resistant. Immunodominance and susceptibility to EAE are associated with a high precursor frequency of PLP 139-151-spe...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Reddy, Jayagopala, Illes, Zsolt, Zhang, Xingmin, Encinas, Jeffrey, Pyrdol, Jason, Nicholson, Lindsay, Sobel, Raymond A., Wucherpfennig, Kai W., Kuchroo, Vijay K.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2004
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC524444/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15492218/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0404444101
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