Chelerythrine down regulates expression of VEGFA, BCL2 and KRAS by arresting G-Quadruplex structures at their promoter regions

A putative anticancer plant alkaloid, Chelerythrine binds to G-quadruplexes at promoters of VEGFA, BCL2 and KRAS genes and down regulates their expression. The association of Chelerythrine to G-quadruplex at the promoters of these oncogenes were monitored using UV absorption spectroscopy, fluorescen...

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Publicado en:Sci Rep
Main Authors: Jana, Jagannath, Mondal, Soma, Bhattacharjee, Payel, Sengupta, Pallabi, Roychowdhury, Tanaya, Saha, Pranay, Kundu, Pallob, Chatterjee, Subhrangsu
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2017
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5244364/
https://ncbi.nlm.nih.gov/pubmed/28102286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40706
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