Porcine Reproductive and Respiratory Syndrome Virus Antagonizes JAK/STAT3 Signaling via nsp5, Which Induces STAT3 Degradation

Signal transducer and activator of transcription 3 (STAT3) is a pleiotropic signaling mediator of many cytokines, including interleukin-6 (IL-6) and IL-10. STAT3 is known to play critical roles in cell growth, proliferation, differentiation, immunity and inflammatory responses. The objective of this...

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Publicat a:J Virol
Autors principals: Yang, Liping, Wang, Rong, Ma, Zexu, Xiao, Yueqiang, Nan, Yuchen, Wang, Yu, Lin, Shaoli, Zhang, Yan-Jin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2017
Matèries:
Pathogenesis and Immunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5244345/
https://ncbi.nlm.nih.gov/pubmed/27881658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02087-16
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