Significance of MDR1 and multiple drug resistance in refractory human epileptic brain

BACKGROUND: The multiple drug resistance protein (MDR1/P-glycoprotein) is overexpressed in glia and blood-brain barrier (BBB) endothelium in drug refractory human epileptic tissue. Since various antiepileptic drugs (AEDs) can act as substrates for MDR1, the enhanced expression/function of this prote...

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Hlavní autoři: Marchi, Nicola, Hallene, Kerri L, Kight, Kelly M, Cucullo, Luca, Moddel, Gabriel, Bingaman, William, Dini, Gabriele, Vezzani, Annamaria, Janigro, Damir
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2004
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC524356/
https://ncbi.nlm.nih.gov/pubmed/15473912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7015-2-37
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