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Biochemical evidence of translational infidelity and decreased peptidyltransferase activity by a sarcin/ricin domain mutation of yeast 25S rRNA

A C→U mutation (rdn5) in the conserved sarcin/ricin domain of yeast 25S rRNA has been shown to cause translational suppression and paromomycin resistance. It also separates the killing from the misreading effect of this antibiotic. We confirm these findings and provide in vitro evidence that rdn5 ca...

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Detalhes bibliográficos
Main Authors: Panopoulos, Panagiotis, Dresios, John, Synetos, Dennis
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC524277/
https://ncbi.nlm.nih.gov/pubmed/15477390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh860
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