Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age‐associated functional decline

Heart performance declines with age. Impaired protein quality control (PQC), due to reduced ubiquitin‐proteasome system (UPS) activity, autophagic function, and/or chaperone‐mediated protein refolding, contributes to cardiac deterioration. The transcription factor FOXO participates in regulating gen...

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Bibliografski detalji
Izdano u:Aging Cell
Glavni autori: Blice‐Baum, Anna C., Zambon, Alexander C., Kaushik, Gaurav, Viswanathan, Meera C., Engler, Adam J., Bodmer, Rolf, Cammarato, Anthony
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Original Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242305/
https://ncbi.nlm.nih.gov/pubmed/28090761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12543
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