Modest overexpression of FOXO maintains cardiac proteostasis and ameliorates age‐associated functional decline

Heart performance declines with age. Impaired protein quality control (PQC), due to reduced ubiquitin‐proteasome system (UPS) activity, autophagic function, and/or chaperone‐mediated protein refolding, contributes to cardiac deterioration. The transcription factor FOXO participates in regulating gen...

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Vydáno v:Aging Cell
Hlavní autoři: Blice‐Baum, Anna C., Zambon, Alexander C., Kaushik, Gaurav, Viswanathan, Meera C., Engler, Adam J., Bodmer, Rolf, Cammarato, Anthony
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5242305/
https://ncbi.nlm.nih.gov/pubmed/28090761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12543
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