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Dopamine promotes NMDA receptor hypofunction in the retina through D(1) receptor-mediated Csk activation, Src inhibition and decrease of GluN2B phosphorylation
Dopamine and glutamate are critical neurotransmitters involved in light-induced synaptic activity in the retina. In brain neurons, dopamine D(1) receptors (D(1)Rs) and the cytosolic protein tyrosine kinase Src can, independently, modulate the behavior of NMDA-type glutamate receptors (NMDARs). Here...
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Publicado no: | Sci Rep |
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Main Authors: | , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Nature Publishing Group
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5241882/ https://ncbi.nlm.nih.gov/pubmed/28098256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40912 |
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