Absence of miR-146a in Podocytes Increases Risk of Diabetic Glomerulopathy via Up-regulation of ErbB4 and Notch-1

Podocyte injury is an early event in diabetic kidney disease and is a hallmark of glomerulopathy. MicroRNA-146a (miR-146a) is highly expressed in many cell types under homeostatic conditions, and plays an important anti-inflammatory role in myeloid cells. However, its role in podocytes is unclear. H...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Biol Chem
Main Authors: Lee, Ha Won, Khan, Samia Q., Khaliqdina, Shehryar, Altintas, Mehmet M., Grahammer, Florian, Zhao, Jimmy L., Koh, Kwi Hye, Tardi, Nicholas J., Faridi, Mohd. Hafeez, Geraghty, Terese, Cimbaluk, David J., Susztak, Katalin, Moita, Luis F., Baltimore, David, Tharaux, Pierre-Louis, Huber, Tobias B., Kretzler, Matthias, Bitzer, Markus, Reiser, Jochen, Gupta, Vineet
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2017
נושאים:
Molecular Bases of Disease
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241746/
https://ncbi.nlm.nih.gov/pubmed/27913625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.753822
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