Combined LRRK2 mutation, aging and chronic low dose oral rotenone as a model of Parkinson’s disease

Aging, genetics and environmental toxicity are important etiological factors in Parkinson’s disease (PD). However, its pathogenesis remains unclear. A major obstacle is the lack of an appropriate experimental model which incorporates genetic susceptibility, aging and prolonged environmental toxicity...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Liu, Hui-Fang, Ho, Philip Wing-Lok, Leung, Gideon Chi-Ting, Lam, Colin Siu-Chi, Pang, Shirley Yin-Yu, Li, Lingfei, Kung, Michelle Hiu-Wai, Ramsden, David Boyer, Ho, Shu-Leong
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241661/
https://ncbi.nlm.nih.gov/pubmed/28098219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep40887
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