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Idiosyncratic Drug-Induced Liver Injury (IDILI): Potential Mechanisms and Predictive Assays

Idiosyncratic drug-induced liver injury (IDILI) is a significant source of drug recall and acute liver failure (ALF) in the United States. While current drug development processes emphasize general toxicity and drug metabolizing enzyme- (DME-) mediated toxicity, it has been challenging to develop co...

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Detalhes bibliográficos
Publicado no:Biomed Res Int
Main Authors: Roth, Alexander D., Lee, Moo-Yeal
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241492/
https://ncbi.nlm.nih.gov/pubmed/28133614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/9176937
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