The MEK-Inhibitor Selumetinib Attenuates Tumor Growth and Reduces IL-6 Expression but Does Not Protect against Muscle Wasting in Lewis Lung Cancer Cachexia

Cachexia, or wasting of skeletal muscle and fat, afflicts many patients with chronic diseases including cancer, organ failure, and AIDS. Muscle wasting reduces quality of life and decreases response to therapy. Cachexia is caused partly by elevated inflammatory cytokines, including interleukin-6 (IL...

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Bibliographic Details
Published in:Front Physiol
Main Authors: Au, Ernie D., Desai, Aditya P., Koniaris, Leonidas G., Zimmers, Teresa A.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2017
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241300/
https://ncbi.nlm.nih.gov/pubmed/28149280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00682
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