Monomerization of RepA dimers by heat shock proteins activates binding to DNA replication origin.
DnaK is a major heat shock protein of Escherichia coli and the homolog of hsp70 in eukaryotes. We demonstrate the mechanism by which DnaK and another heat shock protein, DnaJ, render the plasmid P1 initiator RepA 100-fold more active for binding to the P1 origin of replication. Activation is the con...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1991
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52413/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1896443/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.18.7903 |
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