Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors

Kinase inhibitors are effective cancer therapies, but tumors frequently develop resistance. Current strategies to circumvent resistance target the same or parallel pathways. We report here that targeting a completely different process, autophagy, can overcome multiple BRAF inhibitor resistance mecha...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Mulcahy Levy, Jean M, Zahedi, Shadi, Griesinger, Andrea M, Morin, Andrew, Davies, Kurtis D, Aisner, Dara L, Kleinschmidt-DeMasters, BK, Fitzwalter, Brent E, Goodall, Megan L, Thorburn, Jacqueline, Amani, Vladimir, Donson, Andrew M, Birks, Diane K, Mirsky, David M, Hankinson, Todd C, Handler, Michael H, Green, Adam L, Vibhakar, Rajeev, Foreman, Nicholas K, Thorburn, Andrew
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2017
Matèries:
Cancer Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241115/
https://ncbi.nlm.nih.gov/pubmed/28094001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19671
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